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Oocytes treated with 0.1 mM Epitalon showed significantly improved MMP compared to untreated aged oocytes, demonstrating that Epitalon preserves mitochondrial function during in vitro aging

Wilson WA, Hughes WE, Tomamichel W, Roach PJ

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However, creatine is reversibly converted by creatine kinase into creatine phosphate and is irreversibly cyclized into creatinine through spontaneous loss of one molecule of water, as indicated previously

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Dual Inhibition of MDM2 and XPO1 Synergizes to Induce Apoptosis in Acute Myeloid Leukemia progenitor cells with Wild-type TP53 through Nuclear Accumulation of p53 and Suppression of c-Myc