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Associated symptoms: Hair changes accompanied by fatigue, cold intolerance, dry skin, or changes in menstrual patterns may indicate thyroid dysfunction requiring investigation

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However, the key findings were consistent across multiple ancestral groups, supporting their generalizability

The recent SUMMIT trial investigating tirzepatide therapy in patients with HFpEF provided the first evidence of an improved cardiovascular outcome (a composite of death from cardiovascular causes or worsening heart failure)[11]

The mechanism is indirect, primarily driven by rapid weight reduction and nutritional deficiencies rather than direct drug effects