GLP-1 Medications with a simple generic name of "semaglutide", "liraglutide", "tirzepatide", "dulaglutide", "exenatide", "exenatide microspheres", or "insulin degludec/liraglutide" and at least one of: A pharmaceutical class of "ANTI-OBESITY GLUCAGON-LIKE PEPTIDE-1 RECEP AGONIST" or "ANTIHYPERGLYCEMIC - INCRETIN MIMETICS COMBINATION" A pharmaceutical class that contains "GLP-1" A pharmaceutical subclass that contains the text "GLP-1"

Abbreviations MS: Multiple sclerosis MOG: Myelin oligodendrocyte glycoprotein EAE: Experimental autoimmune encephalomyelitis CNS: Central nervous system BBB: Blood brain barrier LPS: Lipopolysaccharide CSF: Cerebro-spinal fluid GO: Gene ontology FFPE: Formalin-fixed paraffin-embedded PBMC: Peripheral blood mononuclear cells GSEA: Gene set enrichment analysis ADME: Absorption, distribution, metabolism, and excretion MRM: Multiple reaction monitoring ANOVA: Analysis of variance PLSDA: Partial least squares-discriminant analysis CV: Coefficient of variance References Abubakar M, Giri A, Goel F et al (2025) Diabetes, alzheimers disease risk factors, and the cafeteria diet: a comprehensive review
Plant-based compounds like berberine and curcumin have shown early promise in supporting blood sugar control and GLP-1 pathways
Damages lipid membranes, denatures proteins, and impairs receptor function
Supplementary zinc is associated with a reduced rate of symptoms ofimbalanced mood
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