Retatrutide, a GIP, GLP-1, and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial
Interestingly, many hybrids from the Ala u triad scan proved to be potent, demonstrating the good overlaps of the oligourea backbone with the peptide backbone
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A study from the University of Pennsylvania and Cedars-Sinai Medical Center found a 700% increase in use of the drugs for patients without diabetes from 2019 to 2023
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The GLP-1 formulation used in the referenced study is the same active ingredient as in FDA-approved Wegovy for chronic weight management