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Prez-Tilve D, Gonzlez-Matas L, Aulinger BA, et al

The first one is a bit of a controversial one

This included Israel Simon Kleiner and Samuel Meltzer, two American physiologists, based at the Rockefeller University in New York who in 1915 demonstrated with animal experiments the power of intravenously administered pancreatic extracts in lowering blood sugar

Topical dose: 0.01 to 0.1% cream twice daily

Referral is recommended when the diagnosis is unclear, lesions are atypical, or systemic involvement is suspected