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High response rate: 83% of subjects achieved 20% weight reduction

In summary, potassium channel openers, by stabilizing the resting membrane potential and reducing neuronal excitability, target a fundamental mechanism of pathological hyperactivity

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Sources: MHRA/EMC Wegovy SmPC, NICE TA875 (Semaglutide for managing overweight and obesity), NHS medicines information

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Thioether macrocyclic peptides are generated by introducing unnatural N-(chloroacetyl)-d-Trp or N-(chloroacetyl)-Tyr into mRNA-encoded libraries, followed by spontaneous cyclization with Cys residues