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After 1-h incubation at room temperature, the plate was measured for baseline luminescence (TECAN)

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1 The safety profile of RADICAVA ORS was generally consistent across age, race, & gender 1 No overall differences in safety or effectiveness of RADICAVA ORS were observed between geriatric patients over the age of 65 and younger patients, but greater sensitivity of some older individuals cannot be ruled out 1 Low rate of discontinuations due to adverse events (AEs) 3 Only 4 patients discontinued treatment in the first 2 months (4/185)

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Ampk-dependent phosphorylation of GAPDH triggers sirt1 activation and is necessary for autophagy upon glucose starvation

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doi: 10.1021/bi001088w

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