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Oprah Reveals She Stopped Using GLP-1s for 12 Months and Shares Exactly What Happened (Exclusive) The icon, who has cowritten a new book on obesity, tells PEOPLE she 'tried to beat the medication' NEED TO KNOW In 2023, Oprah Winfrey revealed that she was taking GLP-1 weight loss medication, telling PEOPLE the drugs were "a gift" But just months after starting GLP-1s, Winfrey stopped taking the injections and tried to "beat the medication," she says in a new PEOPLE cover story Winfrey says she learned from the experience that being on the drugs "is going to be a lifetime thing" Oprah Winfrey says she was "shaking" when she first revealed in a PEOPLE interview two years ago that she was taking a GLP-1 weight loss medication