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They took years to isolate and produce safely

Online monitoring of metabolite dynamics in continuous fermentor cultures A Biostat A fermentor (Sartorius Stedim Systems GmbH, Guxhagen, Germany) was used to measure population-synchronized metabolic oscillations in continuous cultures with respect to the yeast metabolic cycle [30]

These tumor cells can not consume isocitrate to produce -KG but convert -KG to 2-hydroxyglutaric acid (2-HG)