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Autotomy that occurs long after injury may appear as pain that occurs below the level of the injury (below-level pain) [64, 65], and the late spontaneous worsening may be the result of complete deafferentation of one or several spinal segments the stimulation of the nerve plexus, or dorsal root injury [66]

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TABLE 2 Summary of methods used to identify GLP-1R expressing cells within the gastrointestinal tract

Single-pathway therapies may persist in specific niches where their particular advantages outweigh the benefits of increased complexity, but their role as first-line treatments appears increasingly challenged

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