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Two edge cases deserve explicit framing

Circulation Research 134, 12921305

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Interestingly, homocysteine levels have been positively associated with serum GGT, suggesting elevations in homocysteine may at least partly be due to increased shunting toward glutathione synthesis in response to increased GSH demands, though this has not been proven as of yet

Other Causes of B12 Deficiency (Non-Autoimmune) Dietary insufficiency (e.g., strict vegan or vegetarian diets without supplementation)

Increased incidence of thyrotoxicosis after iodine supplementation in an iodine sufficient area