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Tirzepatide has shown favorable effects on cardiovascular risk markers including blood pressure, lipids, and inflammatory markers, but cardiovascular outcomes trials are still ongoing

Monotreme GLP-1 peptides are resistant to cleavage by human DPP-4 and human serum components but are cleaved in platypus and echidna sera, independently of DPP-4 activity Sequence alignments between human, platypus and echidna GLP-1 proteins (Fig

Projected Prevalence of Obesity in Primary Total Knee Arthroplasty: How Big Will the Problem Get