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The influence of substituents on acidity is more pronounced in DMSO than in water, so Hammett parameters derived from aqueous p K a values actually underestimate substituent effects in reactions performed in non-hydrogen bonding media

Patients at high risk of hepatotoxicity should have serial APAP level and hepatic function panels measured before the completion of NAC

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doi: 10.1007/s10495-015-1195-0