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Together, these findings suggest that Semas ability to engage central appetite-regulating networksparticularly in the hypothalamus, brainstem, and reward centersmakes it a valuable compound for ongoing research into obesity, energy regulation, and neuroendocrine control of eating behavior

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The STEP 1 trial showed around 14.9% average weight loss with the injection

A real-world study from Taiwan 22 showed there was a statistically significant change in HbA1c at 12 months from baseline in each treatment group (dulaglutide: 1.06% [SD: 1.70] and liraglutide: 0.83% [SD: 1.61]), with a significant between-group difference in HbA1c reduction of 0.23% (95% CI 0.38 to 0.08%)

Published studies suggest that semaglutide may be safely administered at 2.4mg/weekly for extended periods without cycling

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