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The molecular mechanisms of the HBD of IGFBP-2 needs to be determined, but the HBD is implicated in downregulating PTEN expression and activates IGF-I signaling pathway in osteoblasts, indicating that the effect of the HBD on bone acquisition is in part mediated by the reduction of PTEN expression in osteoblastic cells

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doi: 10.1152/physrev.1979.59.3.527 18