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Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors

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~41% dermis) and improved hydration (+12%), firmness (+29%), elasticity (+20%) after 56 days

PMID: 40691175 Nat Commun The TEX44-CPT1B axis regulates mitochondrial sheath assembly and fatty acid oxidation in sperm

Despite promising preclinical data, challenges such as poor bioavailability, dose-dependent safety concerns, and the need for large-scale randomized clinical trials and regulatory standardization remain

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