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Makara Kesehatan 2008;12:93-5

Intracellular Glu is produced from glutamine (Gln) catalyzed by glutaminase (GLS, with two different isomers GLS1 and GLS2) [29, 30]

The variations in ROS generation could affect the amounts of oxidized proteins, lipids, and DNA damage, increasing the colons vulnerability to GI disorders at these two intestinal sites (129)

J., Lucia M

Naringenin alleviates renal ischemia reperfusion injury by suppressing ER stress-induced pyroptosis and apoptosis through activating Nrf2/HO-1 signaling pathway

These approaches achieve therapeutic effects through intersecting mechanisms such as restoration of the microbial ecological balance, normalization of microbiota-derived metabolite profiles, and amelioration of gut barrier dysfunction, which contributes to systemic inflammation