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Antioxidant Depletion: In an ironnitrilotriacetic acid rat model of hemochromatosis, renal samples showed increases in reactive intermediates, accompanied by decreased availability of systems that protect against oxidation by iron, such as vitamin E levels, the glutathione system, thiol-specific antioxidants, and superoxide dismutase

Several studies have proposed a direct biochemical interaction between melatonin and the NRF2 pathway

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The HarmonyIntegration setting was used to integrate samples within the macrophage object

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Additionally, Nrf2 , activated by oxidative stress, enhances NOS3 transcription by upregulating antioxidant response elements in the NOS3 promoter (Wu et al., 2019)