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These medications are generally designed for long-term use to help maintain weight loss, underscoring the fact that obesity is a chronic disease that necessitates ongoing treatment and lifestyle modification

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Comorbidities : Other metabolic conditions, such as the presence of type 2 diabetes, osteoarthritis, obstructive sleep apnea, and heart disease, also influence the effect of medication

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These may be contraindications

By targeting GLP-1 + GIP + Glucagon receptors, clinical studies have reported weight loss approaching 24% or more, making it one of the most effective obesity therapies under development