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The additional receptor activation means there are more pathways being affected simultaneously, which some people experience as more noticeable initial adjustment

Kumar S, Garg SKR

That extra pathway is scientifically interesting, but it does not automatically answer practical questions about eligibility, long-term safety, tolerability, access, or cost

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The Integrative Psychopharmacology Framework This brings me to a broader point about how I think about prescribing as a psychiatrist

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