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According to a 2012 review, 29 is the minimum required for complete biological activity.9 The structural difference here means that tesamorelin is a stabilized analog that more closely mimics the hormone on which its based.28 Pharmaceutical status While sermorelin has been discontinued as an FDA-approved drug for growth hormone deficiency, tesamorelin is currently approved as a treatment for HIV-associated lipodystrophy (an accumulation of excess abdominal fat resulting from HIV)

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The circulating leptin level increases in older humans due to decreased leptin receptor expression in peripheral blood monocytes [106]

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Visualization and quantitative densitometry analysis were performed with Molecular Imager Gel Doc XR System v5.2.1 (Bio-Rad Laboratories, Hercules, CA, USA)

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