All TPP-dependent enzymes contain a highly similar TPP-binding domain and its lack in the TKTL1 encoded protein strongly suggests that it is unlikely that TKTL1 is a TPP-dependent protein capable of catalyzing the transketolase reaction
However, human clinical evidence is still limited, and larger, well-controlled trials are needed to clarify safety, efficacy, and appropriate use
Rakza, R., Groussin, P., Benali, K., Behar, N., Mabo, P., Pavin, D., Leclercq, C., Liang, J
On the trade front, the U.S
Some patients explore combinations under medical supervision
Risk Profile: While both have similar side effect profiles related to their mechanism of action, the specific risks and benefits for each depend on the condition being treated and should be discussed thoroughly with a healthcare provider