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10.1016/S0092-8674(00)80108-7 11 HeoY
Metformin alleviates osteoarthritis in mice by inhibiting chondrocyte ferroptosis and improving subchondral osteosclerosis and angiogenesis
Plant Cell 27 , 25452559 (2015)
Together, these elements create a synergistic formula that aims for gradual, steady improvements rather than quick but unsustainable results
(2) Cross-nutrient common mechanistic gaps and future research directions Across all nutrient categories, three critical gaps in mechanistic understanding persist and must be addressed in future research: Quantification of microbiota-metabolite-depression thresholds: for example, the minimum amount of dietary fiber required to elevate fecal butyrate concentrations to levels that alleviate depressive symptoms remains unclear
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