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Delivery Systems and Routes of Administration Injectable Formulations Most approved peptide therapeutics are administered by injection due to their poor oral bioavailability

doi: 10.1016/j.jdermsci.2020.08.006 53

The SURMOUNT-5 trial (published in NEJM, 2025) demonstrated mean weight loss of 20.2% with tirzepatide versus 13.7% with semaglutide over 72 weeks in adults with obesity but without diabetes [10]

Fibrosis (scarring of tissues) increases with age and makes the ovaries less responsive

These results suggest that semaglutide, like other GLP-1RAs, may contribute to promoting healthy lifestyle changes in addition to glycemic control

Some patients experience temporary water retention in the first 2-4 weeks as their body adjusts to hormonal shifts