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Nausea, vomiting, constipation, and appetite suppression are the most frequently reported side effects during the first 48 weeks as your body adapts

Maintaining achieved results through ongoing treatment becomes the appropriate goal once plateau occurs

Cardiovascular and metabolic health investigations

doi:10.1017/S0033291722001106 [*Equal senior contribution.]

How Weekly Semaglutide Doses Activate GLP-1 Receptor Pathways Semaglutide functions as a glucagon-like peptide-1 (GLP-1) receptor agonist, binding to GLP-1 receptors throughout the brain and gastrointestinal system to regulate hunger signals and glucose metabolism

Reduced liver glucose output through glucagon suppression