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However, the administration of SHIRATAMA therapy in clinical settings requires direct intravenous injection, which presents challenges in terms of time commitment and cost, limiting its long-term feasibility

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Yang X, Zhang X, Sun C, Zhao C, Kong X, Zhao M, et al

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Biosci Rep (2019) 39(12):BSR20192009

Another AD study, focused on targeting CD38, showed that CD38 knockdown in APP Swe mutation-expressing transgenic mice enhanced NAD + levels and reduced A plaques in brain extracts, mirrored by some improvement of cognitive performance 270,274