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Double knockout animals for both GIPR and GLP-1R (DIRKO) showed in cortical bone the same bone alterations seen in single GLP-1R KO animals [45]

FIGURE 2 Pyruvate Kinase Activation and Red Blood Cell ATP Patients with pyruvate kinase deficiency (PKD) are susceptible to hemolytic anemia (Table 1) because RBC PK is critical for ATP generation, given the absence of mitochondria in mature RBCs

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Three depression symptom profiles were created using items from the IDS-SR 30 as described in previous studies [2, 39, 40]