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PCD is characterized by low plasma carnitine levels, reduced intracellular carnitine, and increased urinary loss.[5] Carnitine is transported intracellularly via OCTN2, which is expressed predominantly in skeletal and cardiac muscles, and kidneys.[3] Decreased OCTN2 on the plasma membrane results in a reduced intracellular update of carnitine.[5] In kidneys, this results in reduced reabsorption of carnitine, and patients with PCD may lose up to 95% of the filtered carnitine in the urine.[6] The parents of a child with PCD, who are heterozygous carriers, may lose twice or thrice the levels of normal urinary excretion.[6] The plasma concentration of acyl-carnitine esters is also low in PCD.[5] Epidemiology The incidence of Primary carnitine deficiency is different based on ethnicity

[PubMed] [Google Scholar] 111.Cesarec V., Becejac T., Misic M., Djakovic Z., Olujic D., Drmic D., Brcic L., Rokotov D.S., Seiwerth S., Sikiric P

Description Ortho Molecular Products L-Glutathione 60 Capsules: Source of an antioxidant that helps protect cells against the oxidative damage caused by free radicals Glutathione is the master antioxidant in the body and is heavily concentrated in tissues such as the liver, spleen and heart

Hill, L

Reference: Kleinman HK & Sosne G (2012)

These medications act as sedatives, calming the brain and nervous system, which may give them relief during withdrawal