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Characterization of lysosomal acid lipase by site-directed mutagenesis and heterologous expression

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### US Regional Pricing Variations | Region | Compounded Monthly Cost | Telehealth Consultation | Notes | |--------|------------------------|------------------------|-------| | Northeast (NY, NJ, MA, CT) | $350-650 | $150-250 | Higher pharmacy costs | | Southeast (FL, GA, TX, NC) | $250-500 | $100-200 | More competitive pricing | | Midwest (IL, OH, MI, MN) | $280-520 | $100-175 | Moderate pricing | | West Coast (CA, WA, OR) | $300-600 | $150-250 | Premium market | | Mountain West (CO, AZ, UT) | $260-480 | $100-175 | Growing availability | ### How US Patients Access Retatrutide 1