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doi: 10.1046/j.1365-2362.2000.00736.x

Because of its structural differences, IGF-1 LR3 shows reduced affinity for certain IGF-binding proteins (IGFBPs) in vitro, enabling researchers to study more sustained receptor engagement and downstream signaling under controlled conditions

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Chem Biol Interact 413:111489

Upon receptor activation, IGF1R autophosphorylates on tyrosine residues 1131, 1135, and 1136 in the activation loop

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