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Review describing the physiological role of GLP-1 in the central regulation of feeding behaviour, as well the effects of pharmacological stimulation of GLP-1 pathways leading to alterations in CNS activity, reduced food intake and weight loss in obesity and T2DM

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I am confident the pharmaceutical industry will not be funding these trials

In addition to appetite control, GLP-1 injections can improve insulin sensitivity and help regulate blood sugar levels, which is particularly beneficial for people with obesity or those at risk of developing type 2 diabetes

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Neurosci Biobehav Rev 94:271285 Drucker DJ, Buse JB, Taylor K, Kendall DM, Trautmann M, Zhuang D et al (2008) Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study