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These drugs make it unmistakably clear that appetite and weight are deeply biological
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Ipamorelin is the default choice because it works well enough, long enough, with the fewest disruptions to cortisol, prolactin, and appetite
Common causes of injection discomfort: Needle penetration through pain-sensitive dermis Rapid injection speed causing tissue distension Cold medication temperature Medication pH and formulation characteristics Injection into areas with less subcutaneous fat Reusing injection sites without adequate rotation Muscle tension at the injection site can also amplify pain perception
