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The peptide binds GHRH receptors on anterior pituitary somatotroph cells, activates adenylyl cyclase to increase intracellular cAMP, enhances transcription of the GH gene, and stimulates exocytosis of stored GH from secretory granules

A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans

doi: 10.1038/84839

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This leads to the inhibition of inflammatory reactions and acceleration of neuron regeneration through the secretion of interleukin-10, thereby playing an important role in suppressing immunity and neuroprotection in the context of ischemic stroke