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In contrast, the Ischemia-Reperfusion group showed increased fluorescence intensity, indicating the accumulation of nanoparticles
To empirically test this future hypothesis, long-term controlled trials may need to standardize the intervention by assigning either a probiotic or prebiotic regimen aimed at propionate enhancement to subjects with mild cognitive impairment
Furthermore, anticholinergic medications, such as trihexyphenidyl, are used also in PD management but struggle to effectively cross the BBB and often exhibit non-specific binding, leading to undesirable peripheral effects such as dry mouth and cognitive impairment, particularly in elderly patients
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