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Interestingly, a recent study examining the time-dependent effect of low IGF-1 levels on aging outcomes observed that a targeted reduction in liver-derived IGF-1 early (10 d or 5 mo) or later in life (15 mo) improved aspects of lifespan in females, though these effects were most pronounced when IGF-1 was reduced at 5 mo old 19

Depletion of endogenous GSH sensitizes cells to cuproptosis, whereas GSH supplementation mitigates copper-induced proteotoxic stress 164,168

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ROS plays a crucial role in follicular development disorders (161)