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It is believed that this may be a result of side effects caused by the medication, such as dehydration, blood sugar fluctuations, systemic effects on fluid balance, and inflammation
Ferroptosis, a distinct form of cell death driven by oxidative stress, has been implicated in the pathogenesis of various central nervous system disorders, including Parkinsons disease (Zhao et al., 2020), Alzheimers disease ( Topiramate has been proposed as a migraine preventive medication because it inhibits ferroptosis via the glutathione peroxidase 4 (GPX4), GSH, and cystine/glutamate antiporter (System Xc-)
Understanding interactions and appropriate dosing becomes crucial
World Trade Organization, 1994
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