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Preclinical and clinical studies, in fact, demonstrate that glucagon receptor agonism in combination with GLP-1 receptor agonism reduces glucose levels and enables weight loss

In high fat diet (HFD) and streptozotocin (STZ)-induced type 2 diabetic mice model and HK-2 cells, after treatment with metformin (200 mg/kg/d) for 24 weeks, some indicators of mitophagy (LC3II, Pink1, Parkin, Atg5) were examined

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