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Constitutive overexpression of the proto-oncogenes c-myb in Balb/c-3T3 cells increases expression of both IGF-1 and IGF-1R, at least partly through an increased transcriptional activity and in this way abrogates the requirement for IGF-1 in the growing media (Kim et al, 1996)

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The significant demyelination in the CC and PFC may play essential roles in developing depressive-like behaviors, and the beneficial effects of ALC in accelerating the remyelination process may be attributed to providing the necessary energy in this demyelinated mouse model of MS