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In addition, astrocytes, which normally support neurons, become dysfunctional through a process called astrogliosis, which worsens glutamate imbalance and reduces neuronal support (Taylor et al., 2016), and genetic mutationssuch as SOD1 (causing harmful protein accumulation), FUS (interfering with RNA handling), and TBK1 or OPTN (which impair the cell's waste disposal system known as autophagy

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Clin Cancer Res 27:922927 Chen Y, Mant C, Hodges R (2002) Determination of stereochemistry stability coefficients of amino acid side-chains in an amphipathic -helix

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