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Fat burners should not be taken during pregnancy, however, and also by people with heart disease and high blood pressure

Effect size guidelines, sample size calculations, and statistical power in gerontology

Tolerance can develop after 3-6 months in some patients, though this is often dose-dependent

But, in fact, the increase over placebo did not reach statistical significance

[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Higgins J, Sally G

We frequently see patients who struggle with weight gain despite consistent effort due to hormonal imbalances, metabolic dysfunction, or genetic predispositions, where a standard diet alone is not enough