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The top 4 candidate biomarkers of interest identified here belong to different molecular categories (miRNAs, extra-cellular matrix, and cytokines), and are involved in pathophysiological processes common to many diseases, especially extra-cellular matrix remodeling and inflammation
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Downstream effects include concentration-dependent suppression of lipogenesis (50-70% reduction), decreased adipocyte size, and increased basal energy expenditure without appetite suppression
Trimetazidine (60 mg/day for 6 months) was also effective in reducing malondialdehyde compared to baseline among a group of patients with end stage renal disease on hemodialysis and continuous peritoneal ambulatory dialysis [185]
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It is commonly used in laboratory environments where a preserved aqueous solution is required for general solution preparation and research handling
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