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PPAR is also involved in carnitine transport and uptake processes, and treatment with its activator increases the transcript levels of OCTN2 and OCTN3 [195, 196]

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This indicates that 2-AR modulates the cAMP signaling pathway and acts downstream of Ras, providing a potential new strategy for the treatment of ICC 90 .Fig

We reasoned that inhibition of BCATm in these extrahepatic tissues could reduce levels of circulating branched-chain ketoacids or other substrates contributing to accumulation of toxic metabolites upstream of the MMUT lesion in liver