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Ganz T: Defensins: antimicrobial peptides of innate immunity
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For example, in MC3T3-E1 cells cultured in high glucose, NAC inhibits the PI3K/AKT pathway (Liu and Yang, 2016), while in dexamethasone-stimulated MC3T3-E1 cells and human DFSCs cultured under standard conditions, it activates PI3K signaling (Meng et al., 2022)
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Older adults and those with malnutrition, chronic disease, or genetic detoxification polymorphisms may benefit more from targeted glutathione support, but individual assessment by a qualified provider is essential before starting supplementation
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