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Health Council of the Netherlands

Archived from the original on July 30, 2017

The prevalence of melasma can be varied from 1% in the normal population to 50% in the high-risk population

This increase in ATP shuts down membrane ATP-sensitive K + channels, depolarizing plasma membrane, and activating voltage-gated calcium channels (Detimary et al., 1998)

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To establish a new-user cohort design, we excluded individuals who had received either medication class within six months prior to treatment initiation (index date)