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People who dont eat animal products, like vegetarians and vegans, might struggle to get enough B12 through diet alone, although you can find B12 in fortified cereals and soy products

The mechanism was proposed to involve copper-dependent enzymes (notably lysyl oxidase, which catalyzes the cross-linking of collagen and elastin and requires copper as a cofactor), GHK-specific effects on growth factor activity, and downstream gene-expression effects in fibroblasts and other tissue-repair-relevant cell types

[3] That trial is real, controlled, and topical on damaged skin, where the epidermal barrier is already breached