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Graphical Abstract Similar content being viewed by others Introduction Professor Ernest Starling proposed the idea of using a gut hormone for the treatment of diabetes in London in the early 1900s and this idea was first tested by administering gut extracts to individuals with the disease [1]

Conclusion GLP-1 constipation is a common and understandable side effect of how these medications work

Sex and age disparities are also evident: Men are consistently affected at higher rates (24 times) compared to women, and the median age of diagnosis varies by region [5]

Hu, C., Huang, Y

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CFTR silencing in pancreatic -cells reveals a functional impact on glucose-stimulated insulin secretion and oxidative stress response