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Fatigue that doesnt lift with a full nights sleep Tingling, numbness, or a pins-and-needles feeling in the hands or feet A sore, red, or unusually smooth tongue Low mood, irritability, or trouble concentrating Unsteady balance, in more advanced cases Nerve symptoms, especially tingling in the feet, can show up before a blood count looks abnormal, so fatigue alone can miss the picture

Call 911 or seek emergency medical care for chest pressure, sudden shortness of breath, fainting, new weakness on one side, facial drooping, sudden difficulty speaking, or other possible heart-attack or stroke symptoms

Flanagan EW, Spann R, Berry SE, et al

These symptoms can include: Severe mood swings: Intense irritability, sadness, or hopelessness

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Ageing potentiates diet-induced glucose intolerance, -cell failure and tissue inflammation through TLR4