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12 Additionally, DPP4 was found to be significantly expressed in osteoclasts, and its activity was inhibited by the anti-resorptive drug denosumab, suggesting that DPP4 produced by osteoclasts could play a crucial role in bone remodeling and energy metabolism

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Its tumor-suppressive function is executed by directly targeting the mRNA of Homeobox C6 ( HOXC6 ), a transcription factor

Timing also correlates with dose escalation

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