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Curr Drug Metab 8:315323 Back SA, Gan X, Li Y, Rosenberg PA, Volpe JJ (1998) Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion

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60,61 Overview of ferroptosis Ferroptosis is a cellular response to oxidative stress that depends on excess iron, phospholipids (PLs) with polyunsaturated fatty acid chains (PUFAs), and ROS

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and (4) metformin is safe, well-tolerated and cost-effective, making it an attractive addition to a cytotoxic therapeutic regimen, and it can be administered orally alongside infusional 5FU