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These observations support growing evidence that semaglutide's effects extend beyond weight management and glucose control, while also highlighting that weight loss alone may not be an adequate surrogate for predicting cardiovascular benefit

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These drugs are sometimes called dual agonists or doubles. Vikings VK2735 is a double that targets GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, as are Mounjaro and Zepbound

Gastrointestinal losses can result in hypokalaemia, which may manifest as muscle weakness, cramps, cardiac arrhythmias, and constipation

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Conversely, in HF with reduced ejection fraction (HFrEF), especially in advanced stages, caution is necessary due to potential increases in heart rate and arrhythmic events [71]